Aksaray University Journal of Sport and Health Researches
Clinical Research
PDF EndNote BibTex RIS Cite

Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor

Year 2022, Volume: 3 Issue: 2, 193 - 202, 29.12.2022

Hüseyin ERDAL Meryem BEKMEZCİ

Abstract

The aim of this study is to evaluate both dynamic thiol-disulfide and ischemia modified albumin (IMA) levels in cord blood of newborns to patients with oxytocin-induced labor. A total of 30 pregnant women who underwent medical labor induction with oxytocin were compared with 30 women whose labor progressed spontaneously without any kind of induction. The dynamic thiol-disulfide balance was determined by the new colorimetric method developed by Erel et al. IMA levels were analyzed by using albumin cobalt binding test developed by Bar-Or et al. It was found that TAS and OSI levels were higher and TOS levels were lower in the oxytocin-induced group compared to the controls. Native and total thiol levels were found lower while disulfide levels were found higher oxytocin-induced group respect to the control. IMA levels were found significantly different between the patient and control subjects. We indicate that formation of disulfide leads to decrease antioxidant capacity in newborns of oxytocin-induced patients. Dynamic thiol-disulfide homeostasis may contribute to the monitoring of oxidative stress in infants of oxytocin-induced patients and the follow-up of diseases that may arise due to oxidative stress.

Keywords

Newborn, Oxidative stress, Ischemia-modified albumin, Thiol-disulfide homeostasis, Oxytocin induction.

References

  • Alchalabi, H. A., Obeidat, B. R., Jallad, M. F., & Khader, Y. S. (2006). Induction of labor and perinatal outcome: the impact of the amniotic fluid index. Eur J Obstet Gynecol Reprod Biol, 129(2), 124-127. doi: 10.1016/j.ejogrb.2005.10.039
  • Bar-Or, D., Curtis, G., Rao, N., Bampos, N., & Lau, E. (2001). Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem, 268(1), 42-47. doi: 10.1046/j.1432-1327.2001.01846.x
  • Cakirca, G., C. M., Erdal H, Neselioglu S, Erel O, Basarali MK, Cakirca TD. (2018). Investigation of thiol/disulfide homeostasis in familial mediterranean fever patients. Clin Anal Med, 9(3), 231-234. doi: 10.4328/JCAM.5789
  • Demirtas, M.S., Erdal H . Evaluation of thiol-disulfide homeostasis and oxidative stress parameters in newborns receiving photheraphy. J Investig Med. doi: 10.1177/jim-10815589221140594
  • Demirtas, M. S., Erdal H (2022) Evaluation of Thiol Disulfide Balance in Adolescents With Vitamin B12 Deficiency. DOI: https://doi.org/10.21203/rs.3.rs-1318028/v1
  • Erdal, H., Özcan, O., Turgut, F., Neşelioğlu, S., Erel Ö. (2022). Evaluation of dynamic thiol-disulfide balance and ischemia modified albumin levels in patients with chronic kidney disease. MKÜ Tıp Dergisi. 2022;13(47):237-242. https://doi.org/10.17944/mkutfd.947113
  • Erdal, H., Ciftciler, R., Tuncer, S. C., Ozcan, O. (2022). Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia. J Investig Med. doi: 10.1136/jim-2022-002568
  • Erdal, H., Demirtas, M. S., Tuncer, S.C., Ozcan O (2022).Thiol/disulfide homeostasis as a new oxidative stress marker in patients with neonatal transient tachypnea. Ann Clin Anal Med 2022, doi: 10.4328/ACAM.21457
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38(12), 1103-1111. doi: 10.1016/j.clinbiochem.2005.08.008
  • Erel, O., & Neselioglu, S. (2014). A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem, 47(18), 326-332. doi: 10.1016/j.clinbiochem.2014.09.026
  • Eryilmaz, M. A., Kozanhan, B., Solak, I., Cetinkaya, C. D., Neselioglu, S., & Erel, O. (2019). Thiol-disulfide homeostasis in breast cancer patients. J Cancer Res Ther, 15(5), 1062-1066. doi: 10.4103/jcrt.JCRT_553_17
  • Eryilmaz, O. G., Kansu-Celik, H., Erel, O., & Erdogan, S. (2017). Thiol/disulfide parameters as a novel oxidative marker in medical labor induction with oxytocin. Horm Mol Biol Clin Investig, 29(2), 61-65. doi: 10.1515/hmbci-2016-0032
  • Giri, T., Jiang, J., Xu, Z., McCarthy, R., Halabi, C. M., Tycksen, E., Palanisamy, A. (2022). Labor induction with oxytocin in pregnant rats is not associated with oxidative stress in the fetal brain. Sci Rep, 12(1), 3143. doi: 10.1038/s41598-022-07236-x
  • Karacor, T., Sak, S., Basaranoglu, S., Peker, N., Agacayak, E., Sak, M. E., Gul, T. (2017). Assessment of oxidative stress markers in cord blood of newborns to patients with oxytocin-induced labor. J Obstet Gynaecol Res, 43(5), 860-865. doi: 10.1111/jog.13263
  • Korkmaz, H., Onal, D., Alisik, M., Erel, O., & Pehlivanoglu, B. (2020). The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats. Biol Chem, 401(11), 1283-1292. doi: 10.1515/hsz-2020-0190
  • Marconi, A. M. (2019). Recent advances in the induction of labor. F1000Res, 8. doi: 10.12688/f1000research.17587.1 Otal, Y., Kahraman, F. A., Haydar, F. G., & Erel, O. (2021). Dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis. Turk J Med Sci, 51(2), 743-748. doi: 10.3906/sag-1904-55
  • Ozcan, O., Erdal, H., Ilhan, G., Demir, D., Gurpinar, A. B., Neselioglu, S., & Erel, O. (2018). Plasma Ischemia-Modified Albumin Levels and Dynamic Thiol/Disulfide Balance in Sickle Cell Disease: A Case-Control Study. Turk J Haematol, 35(4), 265-270. doi: 10.4274/tjh.2018.0119
  • Ozcan, O., Erdal, H., & Yonden, Z. (2015). İskemi-reperfüzyon hasari ve oksidatif stres ilişkisine biyokimyasal bakiş. Mustafa Kemal Üniversitesi Tıp Dergisi, 6(23), 27-33. Doi: 10.17944/mkutfd.54113
  • Özcan O, E. H., Çakırca G, Yönden Z (2015). Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest, 6(3), 331-336. doi: 10.5799/ahinjs.01.2015.03.0545
  • Rydahl, E., Eriksen, L., & Juhl, M. (2019). Effects of induction of labor prior to post-term in low-risk pregnancies: a systematic review. JBI Database System Rev Implement Rep, 17(2), 170-208. doi: 10.11124/JBISRIR-2017-003587
  • Saugstad, O. D. (2005). Oxidative stress in the newborn--a 30-year perspective. Biol Neonate, 88(3), 228-236. doi: 10.1159/000087586

Oksitosin ile İndüklenen Doğumu Olan Hastalarda Yeni Doğanların Kordon Kanındaki Dinamik Tiyol/Disülfid Homeostazisi ve İskemi-Modifiye-Albümin Düzeylerinin Değerlendirilmesi

Year 2022, Volume: 3 Issue: 2, 193 - 202, 29.12.2022

Hüseyin ERDAL Meryem BEKMEZCİ

Abstract

Bu çalışmanın amacı oksitosine bağlı doğum eylemi olan hastalarda yenidoğanların kordon kanındaki hem dinamik tiyol-disülfid hem de iskemi modifiye albümin (IMA) düzeylerini değerlendirmektir. Oksitosin ile tıbbi doğum indüksiyonu yapılan toplam 30 hamile kadın, doğumu herhangi bir indüksiyon olmaksızın kendiliğinden ilerleyen 30 kadınla karşılaştırıldı. Dinamik tiyol-disülfid dengesi, Erel ve arkadaşları tarafından geliştirilen yeni kolorimetrik yöntemle belirlendi. IMA seviyeleri Bar-Or ve arkadaşları tarafından geliştirilen albümin kobalt bağlanma testi kullanılarak analiz edildi. Oksitosin ile indüklenen grupta kontrollere göre TAS ve OSI seviyelerinin daha yüksek ve TOS seviyelerinin daha düşük olduğu bulundu. Oksitosin ile indüklenen grupta kontrol grubuna göre native ve toplam tiyol seviyeleri daha düşük, disülfid seviyeleri ise daha yüksek bulundu. IMA seviyeleri hasta ve kontrol grupları arasında anlamlı olarak farklı bulundu. Oksitosin ile indüklenen hastaların yenidoğanlarında disülfid oluşumunun antioksidan kapasitede azalmaya yol açtığını düşünüyoruz . Dinamik tiyol-disülfid homeostazı, oksitosin ile indüklenen hastaların bebeklerinde oksidatif stresin izlenmesine ve oksidatif strese bağlı ortaya çıkabilecek hastalıkların takibine katkı sağlayabilir.

Keywords

Newborn, Oxidative stress, Ischemia-modified albumin, Thiol-disulfide homeostasis, Oxytocin induction.

References

  • Alchalabi, H. A., Obeidat, B. R., Jallad, M. F., & Khader, Y. S. (2006). Induction of labor and perinatal outcome: the impact of the amniotic fluid index. Eur J Obstet Gynecol Reprod Biol, 129(2), 124-127. doi: 10.1016/j.ejogrb.2005.10.039
  • Bar-Or, D., Curtis, G., Rao, N., Bampos, N., & Lau, E. (2001). Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem, 268(1), 42-47. doi: 10.1046/j.1432-1327.2001.01846.x
  • Cakirca, G., C. M., Erdal H, Neselioglu S, Erel O, Basarali MK, Cakirca TD. (2018). Investigation of thiol/disulfide homeostasis in familial mediterranean fever patients. Clin Anal Med, 9(3), 231-234. doi: 10.4328/JCAM.5789
  • Demirtas, M.S., Erdal H . Evaluation of thiol-disulfide homeostasis and oxidative stress parameters in newborns receiving photheraphy. J Investig Med. doi: 10.1177/jim-10815589221140594
  • Demirtas, M. S., Erdal H (2022) Evaluation of Thiol Disulfide Balance in Adolescents With Vitamin B12 Deficiency. DOI: https://doi.org/10.21203/rs.3.rs-1318028/v1
  • Erdal, H., Özcan, O., Turgut, F., Neşelioğlu, S., Erel Ö. (2022). Evaluation of dynamic thiol-disulfide balance and ischemia modified albumin levels in patients with chronic kidney disease. MKÜ Tıp Dergisi. 2022;13(47):237-242. https://doi.org/10.17944/mkutfd.947113
  • Erdal, H., Ciftciler, R., Tuncer, S. C., Ozcan, O. (2022). Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia. J Investig Med. doi: 10.1136/jim-2022-002568
  • Erdal, H., Demirtas, M. S., Tuncer, S.C., Ozcan O (2022).Thiol/disulfide homeostasis as a new oxidative stress marker in patients with neonatal transient tachypnea. Ann Clin Anal Med 2022, doi: 10.4328/ACAM.21457
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38(12), 1103-1111. doi: 10.1016/j.clinbiochem.2005.08.008
  • Erel, O., & Neselioglu, S. (2014). A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem, 47(18), 326-332. doi: 10.1016/j.clinbiochem.2014.09.026
  • Eryilmaz, M. A., Kozanhan, B., Solak, I., Cetinkaya, C. D., Neselioglu, S., & Erel, O. (2019). Thiol-disulfide homeostasis in breast cancer patients. J Cancer Res Ther, 15(5), 1062-1066. doi: 10.4103/jcrt.JCRT_553_17
  • Eryilmaz, O. G., Kansu-Celik, H., Erel, O., & Erdogan, S. (2017). Thiol/disulfide parameters as a novel oxidative marker in medical labor induction with oxytocin. Horm Mol Biol Clin Investig, 29(2), 61-65. doi: 10.1515/hmbci-2016-0032
  • Giri, T., Jiang, J., Xu, Z., McCarthy, R., Halabi, C. M., Tycksen, E., Palanisamy, A. (2022). Labor induction with oxytocin in pregnant rats is not associated with oxidative stress in the fetal brain. Sci Rep, 12(1), 3143. doi: 10.1038/s41598-022-07236-x
  • Karacor, T., Sak, S., Basaranoglu, S., Peker, N., Agacayak, E., Sak, M. E., Gul, T. (2017). Assessment of oxidative stress markers in cord blood of newborns to patients with oxytocin-induced labor. J Obstet Gynaecol Res, 43(5), 860-865. doi: 10.1111/jog.13263
  • Korkmaz, H., Onal, D., Alisik, M., Erel, O., & Pehlivanoglu, B. (2020). The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats. Biol Chem, 401(11), 1283-1292. doi: 10.1515/hsz-2020-0190
  • Marconi, A. M. (2019). Recent advances in the induction of labor. F1000Res, 8. doi: 10.12688/f1000research.17587.1 Otal, Y., Kahraman, F. A., Haydar, F. G., & Erel, O. (2021). Dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis. Turk J Med Sci, 51(2), 743-748. doi: 10.3906/sag-1904-55
  • Ozcan, O., Erdal, H., Ilhan, G., Demir, D., Gurpinar, A. B., Neselioglu, S., & Erel, O. (2018). Plasma Ischemia-Modified Albumin Levels and Dynamic Thiol/Disulfide Balance in Sickle Cell Disease: A Case-Control Study. Turk J Haematol, 35(4), 265-270. doi: 10.4274/tjh.2018.0119
  • Ozcan, O., Erdal, H., & Yonden, Z. (2015). İskemi-reperfüzyon hasari ve oksidatif stres ilişkisine biyokimyasal bakiş. Mustafa Kemal Üniversitesi Tıp Dergisi, 6(23), 27-33. Doi: 10.17944/mkutfd.54113
  • Özcan O, E. H., Çakırca G, Yönden Z (2015). Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest, 6(3), 331-336. doi: 10.5799/ahinjs.01.2015.03.0545
  • Rydahl, E., Eriksen, L., & Juhl, M. (2019). Effects of induction of labor prior to post-term in low-risk pregnancies: a systematic review. JBI Database System Rev Implement Rep, 17(2), 170-208. doi: 10.11124/JBISRIR-2017-003587
  • Saugstad, O. D. (2005). Oxidative stress in the newborn--a 30-year perspective. Biol Neonate, 88(3), 228-236. doi: 10.1159/000087586

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Hüseyin ERDAL
Aksaray Üniversitesi,Tıp Fakültesi
0000-0003-0786-5077
Türkiye

Meryem BEKMEZCİ
AKSARAY ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0002-1861-3556
Türkiye

Publication Date December 29, 2022
Submission Date November 12, 2022
Acceptance Date December 7, 2022
Published in Issue Year 2022Volume: 3 Issue: 2

Cite

Bibtex @clinical research { asujshr1203106, journal = {Aksaray University Journal of Sport and Health Researches}, eissn = {2757-6310}, address = {Aksaray Üniversitesi Rektörlük İdari Birimler Spor ve Sağlık Alanında İhtisaslaşma Koordinatörlüğü Aksaray/Merkez, 68100}, publisher = {Aksaray University}, year = {2022}, volume = {3}, number = {2}, pages = {193 - 202}, doi = {10.54152/asujshr.1203106}, title = {Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor}, key = {cite}, author = {Erdal, Hüseyin and Bekmezci, Meryem} }
APA Erdal, H. & Bekmezci, M. (2022). Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor . Aksaray University Journal of Sport and Health Researches , 3 (2) , 193-202 . Retrieved from http://asujshr.aksaray.edu.tr/en/pub/issue/73325/1203106
MLA Erdal, H. , Bekmezci, M. "Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor" . Aksaray University Journal of Sport and Health Researches 3 (2022 ): 193-202 <http://asujshr.aksaray.edu.tr/en/pub/issue/73325/1203106>
Chicago Erdal, H. , Bekmezci, M. "Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor". Aksaray University Journal of Sport and Health Researches 3 (2022 ): 193-202
RIS TY - JOUR T1 - Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor AU - HüseyinErdal, MeryemBekmezci Y1 - 2022 PY - 2022 N1 - DO - T2 - Aksaray University Journal of Sport and Health Researches JF - Journal JO - JOR SP - 193 EP - 202 VL - 3 IS - 2 SN - -2757-6310 M3 - UR - Y2 - 2022 ER -
EndNote %0 Aksaray University Journal of Sport and Health Researches Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor %A Hüseyin Erdal , Meryem Bekmezci %T Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor %D 2022 %J Aksaray University Journal of Sport and Health Researches %P -2757-6310 %V 3 %N 2 %R %U
ISNAD Erdal, Hüseyin , Bekmezci, Meryem . "Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor". Aksaray University Journal of Sport and Health Researches 3 / 2 (December 2022): 193-202 .
AMA Erdal H. , Bekmezci M. Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor. ASUJSHR. 2022; 3(2): 193-202.
Vancouver Erdal H. , Bekmezci M. Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor. Aksaray University Journal of Sport and Health Researches. 2022; 3(2): 193-202.
IEEE H. Erdal and M. Bekmezci , "Evaluation of Dynamic Thiol /Disulfide Homeostasis and Ischemia- Modified-Albumin Levels in Cord Blood of Newborns to Patients with Oxytocin-Induced Labor", Aksaray University Journal of Sport and Health Researches, vol. 3, no. 2, pp. 193-202, Dec. 2022, doi:10.54152/asujshr.1203106
 Download Cover Image

An International Peer-Reviewed e-Journal / Period: Biannually / Founded: 2020 / Publisher: Aksaray University

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.